Duration of carriage of multidrug-resistant bacteria in dogs and cats in veterinary care and co-carriage with their owners
Duration of carriage of multidrug-resistant bacteria in dogs and cats in veterinary care and co-carriage with their owners
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Background: The emergence and spread Hayward Sense of multidrug-resistant organisms (MDROs) represent a threat to human and animal health.Objectives: To assess duration of carriage of MDROs in dogs and cats presented to veterinary clinics/hospitals in Switzerland.To estimate prevalence, duration of and risk factors for MDRO carriage in their owners and the occurrence of co-carriage in owner-pet pairs.Methods: Prospective, longitudinal, observational study.
Nasal swabs and fecal samples were collected from 50 owners of dogs and cats presented to 3 large veterinary hospitals, 1 medium-sized clinic and 1 practice.If pet or owner tested positive for a MDRO, follow-up samples were collected for up to 8 months.Methicillin-resistant (MR) Staphylococcus aureus, MR S.pseudintermedius, MR coagulase-negative staphylococci (MRCoNS), MR Macrococcus spp.
, cephalosporinase- and carbapenemase-producing (CP) Enterobacterales were isolated and further characterized by MALDI-TOF MS, microdilution, β-lactam resistance gene detection, REP/ERIC-PCR, multilocus sequence typing or whole-genome sequencing.Risk factors for MDRO carriage in owners were explored based on questionnaire-derived data.Results: Five out of 50 owners carried 3rd generation cephalosporin-resistant Enterobacterales (3GC-R-Ent.), and 5/50 MRCoNS.
In 3 dogs and 4 cats carriage of 3GC-R-Ent.persisted for up to 136 days after discharge (median 99 days, IQR 83 days, range 36–136 days), in two cats isolates were carbapenem-resistant.Owner-pet co-carriage was not observed.No specific risk factors for MDRO carriage in owners were identified.
Conclusions: Chandeliers After discharge from veterinary care, dogs and cats may carry 3GC-R-Ent.for prolonged time periods.Carriage of MDROs was common in owners, but pet-owner co-carriage of the same MDRO was not observed.